The Day Eazy E Died is the story of Kwame Woodson's, a 24 year old Harlemite, journey to manhood. After one of his idols, rap artist Eazy-E, discloses that he is dying from complications from AIDS, Kwame starts to reflect on the choices he has made in his young life, realizing he can no longer ignore the disease, and decides to get tested for the HIV virus – but doesn’t tell his girlfriend, Queen McMillian. As Kwame waits for the results, his world is turned inside out with his dead end job at a record shop, his relationship with his daughter, his budding rap career, his attempt to reunite his older brother and father, and his love life which all seem to squeeze in on him.